Effectiveness of 3% hypertonic saline nebulization in acute bronchiolitis among Indian children: A quasi-experimental study

Harsh V Gupta; Vivek V Gupta; Gurmeet Kaur; Amitoz S Baidwan; Pardeep P George; Jay C Shah; Kushal Shinde; Ruku Malik; Neha Chitkara; Krushnan V Bajaj

doi:10.4103/2229-3485.179434

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ORIGINAL ARTICLE

Year : 2016 | Volume : 7 | Issue : 2 | Page : 88-93

Effectiveness of 3% hypertonic saline nebulization in acute bronchiolitis among Indian children: A quasi-experimental study

Harsh V Gupta¹, Vivek V Gupta², Gurmeet Kaur¹, Amitoz S Baidwan³, Pardeep P George⁴, Jay C Shah⁵, Kushal Shinde², Ruku Malik², Neha Chitkara⁶, Krushnan V Bajaj⁷
¹ Department of Pediatrics, GGS Medical College and Hospital, Faridkot, Punjab, India
² Department of Public Health Dentistry, Pacific Dental College and Hospital, Udaipur, Rajasthan, India
³ Department of Pediatrics, Chaitanya Hospital, Chandigarh, India
⁴ Department of Orthodontics, AL Azhar Dental College and Hospital, Kerala, India
⁵ Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, Ahmedabad, Gujarat, India
⁶ Department of Oral Medicine and Radiology, Mahatma Gandhi Dental College and Hospital, Jaipur, Rajasthan, India
⁷ Department of Prosthodontics, Pacific Dental College and Hospital, Udaipur, Rajasthan, India

Correspondence Address:
Harsh V Gupta
Department of Pediatrics, GGS Medical College and Hospital, Faridkot, Punjab
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/2229-3485.179434

Objective: To compare the effects of 3% hypertonic saline (HS) and 0.9% normal saline with nebulized 0.9% normal saline with salbutamol in patients of acute viral bronchiolitis. Materials and Methods: Participants were divided into three groups, that is, 3% HS group, 0.9% normal saline group and 0.9% saline with salbutamol group. Four doses at interval of 6 h were given daily until discharge. Average CS score and length of hospital stay were compared. One-way analysis of variance paired t-test and Chi-square test were utilized for statistical analysis. Results: The mean ages of the patients in three groups were 6.03 ± 3.71, 5.69 ± 3.34 and 5.48 ± 3.35 respectively. The 3^rd day CS scores for all the groups were 1.0 ± 1.1, 1.9 ± 1.1 and 3.3 ± 0.5 respectively (P = 0.000). The average length of hospital stay was 3.4 ± 1.7, 3.7 ± 1.9 and 4.9 ± 1.4 days respectively (P = 0.001). Conclusion: The present study concludes that 3% HS nebulization (without additional bronchodilators) is an effective and safe treatment for nonasthmatic, moderately ill patients of acute bronchiolitis. The economic benefit of this comparably priced modality of treatment can be enormous in terms of hospital costs with parents returning to work sooner.

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