Perspectives in Clinical Research

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 12  |  Issue : 4  |  Page : 223--228

Comparison of efficacy, safety, and cost-effectiveness of sertaconazole and luliconazole cream in patients with dermatophytoses: A prospective, randomized, open-label study


Ganesh N Dakhale1, Ashish V Gupta2, Jayesh I Mukhi3, Mrunalini V Kalikar2 
1 Department of Pharmacology, AIIMS, Nagpur, Maharashtra, India
2 Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India
3 Department of Dermato-Venereo-Leprology, Government Medical College, Nagpur, Maharashtra, India

Correspondence Address:
Dr. Jayesh I Mukhi
Department of Dermato-Venereo-Leprology, Government Medical College, Nagpur - 440 003, Maharashtra
India

Objective: To compare efficacy, safety, and cost-effectiveness of sertaconazole (2%) and luliconazole (1%) cream in patients with dermatophytoses. Materials and Methods: Sixty-four patients with tinea corporis and tinea cruris infections were enrolled in this single-center, randomized, open–label, parallel study. Following inclusion and exclusion criteria, patients were randomly divided into two treatment groups and received either sertaconazole 2% cream applied topically twice daily for 4 weeks and luliconazole 1% cream once daily for 2 weeks. At follow-up, efficacy was assessed clinically using 4-point physician global assessment (PGA) scale, composite score, and mycologically by KOH mount. Safety was assessed by monitoring adverse drug events at each visit. Results: The primary efficacy variables including changes in pruritus, erythema, vesicle, and desquamation (4-point PGA) were significantly (P < 0.0001) improved in both the groups, at the end of treatment. There was a significant reduction in mean total composite score (pruritus, erythema, vesicle, and desquamation) after the end of treatment in the sertaconazole group (P = 0.0002) compared to the luliconazole group. Both the groups showed equal negative mycological assessment. Both the study drugs were well tolerated. Only one patient in the sertaconazole group showed allergic contact dermatitis. Conclusion: Sertaconazole was better than luliconazole in relieving signs and symptoms during the study and follow-up period, but cost-effectiveness wise, luliconazole was better than sertaconazole.


How to cite this article:
Dakhale GN, Gupta AV, Mukhi JI, Kalikar MV. Comparison of efficacy, safety, and cost-effectiveness of sertaconazole and luliconazole cream in patients with dermatophytoses: A prospective, randomized, open-label study.Perspect Clin Res 2021;12:223-228


How to cite this URL:
Dakhale GN, Gupta AV, Mukhi JI, Kalikar MV. Comparison of efficacy, safety, and cost-effectiveness of sertaconazole and luliconazole cream in patients with dermatophytoses: A prospective, randomized, open-label study. Perspect Clin Res [serial online] 2021 [cited 2022 Jan 26 ];12:223-228
Available from: https://www.picronline.org/article.asp?issn=2229-3485;year=2021;volume=12;issue=4;spage=223;epage=228;aulast=Dakhale;type=0