Close
  Indian J Med Microbiol
 

Figure 1: Interpretation of the results of a non-inferiority study. The vertical solid line represents the observed effect of the current standard, and the vertical dotted line is located at a distance of the predetermined inferiority margin (or delta) below it. For non-inferiority to be established, it is expected that the lower bound of the 95% confidence intervals (CIs) of the observed effect of the new treatment is not below the dotted line. Hence, for the lower three lines (lines 5–7), non-inferiority is not established. For the next three lines (lines 2–4), non-inferiority is established. The result represented by line 1 establishes not only non-inferiority but also superiority (since the lower bound of the 95% CIs of the effect of the new intervention exceeds the observed effect of the comparator or the current standard intervention)

Figure 1: Interpretation of the results of a non-inferiority study. The vertical solid line represents the observed effect of the current standard, and the vertical dotted line is located at a distance of the predetermined inferiority margin (or delta) below it. For non-inferiority to be established, it is expected that the lower bound of the 95% confidence intervals (CIs) of the observed effect of the new treatment is not below the dotted line. Hence, for the lower three lines (lines 5–7), non-inferiority is not established. For the next three lines (lines 2–4), non-inferiority is established. The result represented by line 1 establishes not only non-inferiority but also superiority (since the lower bound of the 95% CIs of the effect of the new intervention exceeds the observed effect of the comparator or the current standard intervention)